Samsung's vertically integrated supply chain allows the company to produce all aspects of LED lights, including chips, PKGs, modules, light engines and lamps.
We observed striking enrichment of known ID susceptibility genes [ 48- 51] in two downregulated modules, light cyan and salmon.
Several modules (light cyan, yellow, pink and red) were enriched with neuronal cell markers (see Figure 4).
Among them, FOXO proteins, which regulate neuronal polarization and positioning [ 76] and synaptic function and memory consolidation [ 30], have binding targets enriched in six out of seven TS-associated modules (light cyan, salmon, magenta, black, purple, and red).
Taken together, these results suggest that the two upregulated modules (light green and magenta), which also represent the convergence of TS and ASD at the level of gene expression, are likely to be mediated via the calcium/NFAT signaling pathway.
Remarkably, the top two most disease correlated modules (light green and light cyan; R-square >0.8; Figure 2A and B) included dysregulated genes previously implicated in neurodevelopmental diseases, such as YWHAE Miller-Diekerr Syndrome) [ 64], ERC1 (12p13.31 deletion associated developmental delay) [ 65], and VAV3 (schizophrenia) [ 66].
The CCD-based test strip reader was composed of six modules, including a light source module, sample module, power module, acquisition module, radiator module, and PC module.
Among the 9 AA-specific and SI-associated modules, the "light yellow" module is most enriched for the transcripts positively correlated with SI in AAs (p = 6.95E-09).
Module 2: light source for modulation.
Toledo-Ortiz, G. et al. The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription.
