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The head module is thought to provide the greatest impact in controlling overall transcription primarily by shifting the transcription machinery from active to inactive state rather than serving as a binding site for other transcriptional regulators.
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Originally the ERK module was thought to mediate cell proliferation and differentiation.
Each of the four modules is thought to act both independently and interdependently; the ligands identified for each domain are specified in Figure 1A [1]–[3].
17– 19 Network segregation into more independent modules is thought to be a mechanism for containment of (pathological) activity, suggesting that increased functional connectivity between modules leads to higher seizure frequency.
Because both frames and modules are thought to be neural circuits, and circuits are heritable (Cosmides and Tooby 1997), any frame or module may be adaptive.
These domain-specific modules are thought to have evolved separately and for specific purposes and are not integrated with each other (Hirschfeld and Gelman 1994).
The AAA+ modules are thought to be arranged sequentially around the head (King, 2000; Mocz and Gibbons, 2001; Serohijos et al., 2006), and support for this arrangement for AAA1 AAA4 has been obtained (Takahashi et al., 2004).
BRDs are often associated with other protein-interaction modules, a mechanism that is thought to generate high target selectivity and increased binding affinity with substrates owing to avidity that is generated on simultaneous binding of several interaction domains.
Glial cells are also associated with the blood vessels; communication between these cells may be important for RMS migration, for example, in BDNF (brain-derived neurotrophic factor), a growth factor that is thought to module RMS migration.
It is thought that such modules yield robust and adaptable systems [ 7].
Therefore, the bisecting GlcNAc is thought to insulate relevant modules, as shown in Figure S2 where the junctions of different modules only contain glycans without bisecting GlcNAc.
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