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This can be done by placing the leading (underlined) and trailing (overlined) 1's of each row of the "matrix module" in specific positions, leaving the other positions free to assume any binary value.
It is therefore possible that the MBD1 CxxC-3 domain may act as a relevant targeting module in specific instances where DNA methylation levels are drastically reduced, for example, in pre-implantation embryos [ 96].
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By using genetic engineering to mix the modules in specific proportions, proteins with defined strength and elasticity can be designed, which have many potential medical and engineering uses.
The restriction endonuclease PvuII has been introduced as a sequence-specific cleavage module in highly-specific nucleases for gene targeting.
Module co-expression was evaluated by calculating the average pair-wise Pearson correlation between all genes for a module in a specific dataset.
However, little is known about the modules that exist in miRNA-gene regulation systems, and even less is known about these modules' role in specific biological processes and key regulation assemblies.
Analyzing the distribution patterns of the promiscuous PWWP domain in ancestrally related genomes from the plant and metazoan lineages we follow the tendencies for the PWWP domain to appear as a single module, in species-specific multidomain arrangements, and as evolutionarily conserved cassettes transmitted as stable units.
The regulatory effect of SMAD complex likely depends on transcriptional modules, in which the SMAD binding elements and partner transcription factor binding sites (SMAD modules) are present in specific context.
We found that different modules were enriched in specific ontologies (Table 7), reflecting the modularity of gene expression.
Curriculum data extracted: Provision of pain teaching within a dedicated pain module, within other medical modules or within the broader curriculum (eg, as a theme, rather than in specific modules).
In the regulatory networks of the nine modules, DNA methylation and genomic elements are present only in specific modules, implying that they are not necessarily common regulatory initiators.
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CEO of Professional Science Editing for Scientists @ prosciediting.com