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A comprehensive methodology must be devised to meet not only the classical objective of parameter screening for parameter estimation but also the objective of performing model diagnosis by qualitatively and quantitatively checking the module importance and interactions.
In this methodology, we successively perform the analysis of model nonlinearity, module importance ranking and its evolution with time, module-by-module parameter screening, quantitative analysis of both intra- and inter-module interactions, and the analysis of the complete model with a reduced number of parameters due to parameter screening.
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One can view the correlation of k.in and essentiality as a test of the modules importance.
Recently, we used this approach to identify a gene module of importance for the extent of coronary atherosclerosis [14].
However, OSS also yielded an intriguing result on its own in that the inhibitory feedback effect to SOS by active ERK in the MAPK module gained importance in controlling the sustained ERK profile (see Figure 7(b)).
In the descriptor module, variable importance and patient segmentation are described.
Our approach is based on the hypothesis that tumors target specific biological modules of critical importance, and that such modules can be algorithmically identified based on network topology alone.
The results let us to set design criteria, which account for the Young's module and the importance of an adequate machining and further adjustment of clearances on the shaft-bearing system, thus improving the reliability of such elements.
The feature importance module enables researchers to interpret models in terms of feature importance.
Indeed, it has been shown that the majority of human kinases contain at least one lipid-binding module, demonstrating the importance of the peripheral protein lipid association in many cellular events.
To compare the performances of unsigned and signed WGCNA in identifying gene groups that are important for the regulation of the pluripotent state, we defined gene modules in unsigned and signed networks and assessed module function and importance by determining gene ontology terms associated with each module and examining module membership of genes known to play a role in ES cells.
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