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Biochemically, each motility module exhibited a different distribution of the actin-related protein VASP, while inhibition of actin polymerization revealed different dependencies on barbed-end polymerization.
This data provided a general kinematic fingerprint for the periodic blebbing and continuous protrusion motility modules while showing that each motility module exhibited a different dependence to barbed-end availability.
Interestingly, each module exhibited a unique functional specialization because only 6 of the total 117 GO terms were shared (represented by multiple colored bars in Fig. 3a).
We observed that different genes within the same FEM module exhibited a tendency for their DNAm and mRNA levels to deviate from the normal tissue in the same tumour samples (Fig. 6a, Additional file 1: Figure S7).
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This module exhibited an enrichment of terms related to RNA processing, including ncRNA and tRNA.
Strikingly, nearly every gene in this module exhibited an age-related expression increase in liver, kidney, cerebellum, cortex, eye, aorta, lung, heart, hippocampus and whole brain.
The helium coolant at the outlet of the pebble bed core of the 10 MW High Temperature Gas-cooled Reactor-Test Module exhibits a severe radial temperature deviation.
The assumption of LO-refinement is that the macromolecular complex can be treated as a combination of multiple modules, with each module exhibiting a relatively rigid conformation within our interested resolution.
Başol et al. reported a total-area efficiency of 13.76% for a 0.48 cm2 device, 12.5% for cells with area of 120 cm2, and 10% for a 1.07 moduleulexhibitingng a total output of 107.5 W (Vm = 38.2 V and Im = 2.8 A) on flexible stainless steel (SS) substrates [98].
Similarly in response to a localized Gaussian input signal, the module exhibits a localized dip for exactly the same reason.
The cell cycle module, which is the first non-core module, exhibits a similar plateau with the exception of the Luminal A subtype which is closer to normal.
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