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This result is consistent with a previous study demonstrating elevated Sox2, among other pluripotency factors, in an ES cell-like expression module discovered in diverse human epithelial cancers [76].
The most prominent individual TFBS module discovered in six of the seven ZNF promoter regions (not in that of ZNF16), was made up of EGR1 and SP1, both C2H2 zinc finger proteins.
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Users can browse motifs and motif modules discovered in each dataset and in any given genomic region.
Functional analysis of modules discovered in this analysis reveals strong enrichment of cancer-related pathways and known cancer genes.
As shown in Table 1, the number of conserved modules discovered in the human network increased from 74 (spanning 457 unique proteins) to 94 (spanning 727 unique proteins).
In the second step, distinct subgraphs that uniquely exist in single networks were identified from the modules discovered in the first step.
Indeed, in Stensola et al. (2012), 4 5 modules were discovered in recordings spanning up to 50% of the dorsoventral extent of MEC; extrapolation gives a total module number consistent with our estimate.
Because it is likely that additional TA modules will be discovered in E. coli, we chose to examine His6-GalE tagging in cells lacking the Lon protease, which is required for the activation of all known E. coli RNase toxins [31], [36], [37].
Users can also download the list of all occurrences of the motif module with their TFBSs under given conditions., The complete list of motif modules discovered for each motif in each dataset, which may not be validated by known interacting TF pairs, can be found in the download page.
One of these is the Mediator complex, the conserved four-module multiprotein unit initially discovered in yeast and later described in fungi, metazoans and plants (Mathur et al. 2011).
Computer investigators said that both the "I Love You" program and the password-stealing modules discovered earlier had references to Amable Mendoza Aguiluz Computer College, which they said had seven campuses in the Philippines.
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