Our structural analysis of the subcomplexes provided direct visualization of the independent association of the N- and C-Modules with SWR1, as suggested by previous biochemical studies (Wu et al., 2009).
Ubp8 and Sgf11 are part of a discrete functional module within the SAGA complex as suggested by genetic interaction and microarray analysis [ 43] and Ubp8 is dispensable at promoters of several SAGA-dependent genes [ 44].
The bending between domains R2 and R3 could explain the invagination in the central part of the vault particle, with the R1 module located in this central part, as suggested earlier by cryo-EM and mutational studies (Mikyas et al, 2004).
A component of the disease seems to be abnormal development of the brain, which is blocked in a juvenile stage, as suggested by the modules that fail to be downregulated in patients with schizophrenia.
As suggested in Section 2.2, the deterministic module now works in an optimized configuration with a maximum of one reflection.
As suggested by increasing evidence, protein interaction modules that are conserved across species may exist.
We use GO to build our reference set of functional modules, with all IEA (inferred from electronic annotation) terms removed, as suggested in Rhee et al. (2008).
Genes possessing module-specific chromatin patterns would be expected to have expression differences, as suggested in previous studies [28], [50].
> -wrap-foot> > The number of modules K was set to 50 for the non-negative matrix factorization method (SNMNMF) as suggested in Zhang et al. (2011).
