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The proteins in this module are involved in the transport of a wide range of molecules.
In humans, five distinct proteins containing a RecQ-like module are involved in a set of diverse nucleic acid transactions, including DNA replication, recombination and repair.
The blue module is the most significantly enriched for Suz12 binding further supporting the idea that genes in this module are involved in ES cell differentiation.
Intriguingly, 14 of the top 50 hub genes of the CBpos5 module are involved in protein folding, all of which share very high connectivity.
Most of chemokines present in the cytokines/MHC class I module are involved in recruiting T cells, monocytes/macrophages and neutrophils: e.g. CX3CR1/CX3CL1, CXCL9 and CXCR2 genes.
Based on these observations, and the fact that the closest homologs for many of the genes in this module are involved in secondary wall formation in Arabidopsis, we assumed that Module 44 is associated with secondary wall synthesis.
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That is, the communication module is involved in the authentication protocol implementation.
The DAVID functional annotation clustering tool [22] then identified the significantly over-represented biological process each module was involved in (Figure 3).
The second module is involved in substrate binding and evidence suggests is localized primarily to the large lobe, in the region named the substrate/peptide binding groove (named from kinase-peptide co-crystal structures).
First, we compiled a list of cellular processes in which the genes composing each module were involved.
CT-PPI modules, which reflect the cooperation between CT and PPI in a module, were involved in essential cell functions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com