Rather, toporthology should be used in combination with other data, such as regulatory module predictions and structural similarity, for assigning functions to genes.
During the last decade, tremendous progress has been made toward understanding the atomic architecture of the ZP module and the structural basis of its polymerization.
The two phage genomes had a synteny in the structure module and shared many structural genes, while little similarity was found in the DNA replication/metabolism module.
Understanding the organization of modules and their structural and functional roles emerges as a new challenge when studying biological networks.
We computationally extracted 15 composite functional modules, and found structural consistency between co-transcriptional regulation interaction sub-network and protein-protein interaction sub-network that was well correlated with their functional hierarchy.
The module containing DNA packaging and structural proteins is the largest module of the Sf101 phage, and is predicted to contain 15 orfs (orf 1 to 15).
For example, the C. thermocellum type-I dockerin module displays internal sequence and structural symmetry that provide a dual mode of binding resulting in two different orientations of the dockerin-borne enzyme [ 60, 61].
Promoter patterns of H3K4me3 and H3K27me3 corresponded strongly with coordinated expression changes of regulatory gene modules, such as HOX and microRNA genes, and structural gene modules, such as desmosome and gap junction genes.
HS-AFM imaging of the Walker mutants dissected the distinct roles of the AAA1 and AAA2 modules in the formation and structural dynamics of TClpB oligomers (Fig. 5).
Design of the front end, floor and structural modules was carried out under the direction of Volkswagen AG, which was in charge of overall co-ordination of the SLC project.
