Sentence examples for modulator that has from inspiring English sources
The goal of an ideal selective estrogen receptor modulator that has all the beneficial effects of estrogen receptor modulation without adverse side effects seems increasingly achievable with improving drug design.
Ulipristal acetate is a selective progesterone receptor modulator that has been demonstrated to be an effective 3-month pre-operative treatment for moderate to severe symptoms of uterine fibroids in adult women of reproductive age.
We are unaware of any other modulator that has this distinctive genetic behavior.
Raloxifene is a selective estrogen-receptor modulator that has been shown to prevent bone loss.
Interestingly, FTY720 is a shingosine 1-phosphate (S1P) receptor modulator that has already been used in clinical trials to treat relapsing multiple sclerosis and to prevent organ rejection following renal transplantation.
Breast cancer is the most commonly diagnosed cancer in women worldwide, and it is estimated that 1.5 million new cases will be diagnosed in 2010. 1 Tamoxifen is a selective oestrogen receptor modulator that has been used for the treatment of breast cancer for over three decades.
NO is a potent immune-modulator that has been implicated in both immune response against the malaria parasite [ 15] and malaria pathology [ 29].
The molecular determinants of the modulator binding sites (MBS), analysis of particular MBS electrostatics, and the specific loss or gain of binding after mutations have revealed modulators that have strong potential affinities for specific MBS on given subunits and the role of key amino acids in either promoting or obstructing modulator binding.
On the other hand, the large thermo-optic coefficient of silicon also makes it possible to manipulate the refractive index by means of both thermo-optical and electro-optical effects – in order to create compact modulators that have been demonstrated in both PhC and PhW formats [7, 8].
Several of the other small molecule modulators that have been curated share scaffolds and are crossover ligands.
Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM) that has antiestrogenic effects on breast and endometrial tissue and estrogenic effects on bone, lipid metabolism, and blood clotting.
