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Currently, the first-line agent for of ER a+breast cancer treatment is tamoxifen, [ 38] a selective ER modulator that antagonizes some in vivo effects of estrogens [ 39]; however, most tamoxifen-responsive breast cancer patients become tamoxifen resistant [ 40].
Current endocrine therapies for ERα breast cancer include: tamoxifen, the selective ER modulator that antagonizes ERα function; fulvestrant, the pure anti-estrogen that degrades/downregulates ERα; and aromatase inhibitors (AIs) (letrozole, anastrozole, and exemestane), which suppress estrogen production in peripheral tissues by blocking the aromatase enzyme.
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Then this spring, Intel researchers led by materials scientist Ling Liao reported a silicon modulator that runs at 10 gigahertz, roughly on par with other optical modulators.
Another possibility is that these chromosomes bear an opposing mark that antagonizes PRC2 activity.
"If that antagonizes them, they should stop trying to kill us".
In addition, one of the putative DELLA targets, XERICO, promotes accumulation of abscisic acid (ABA) that antagonizes GA effects.
The agents that antagonize estrogenic action (for example, tamoxifen (TAM) and other selective estrogen receptor modulators (SERMs)) are used clinically to treat ER+ breast cancer patients.
Mr. Letta might, therefore, be tempted to steer clear of any changes that antagonize Mr. Berlusconi.
Perón enacted policies that antagonized the rich.
This result indicated that Alcaligenes sp. CT10 secreted the unknown factor that antagonized against Pseudomonas sp. ZS1.
Currently, there are no antagonists that antagonize all 3 receptors at the same time; therefore we have to rely on studies using individual antagonists that antagonize each receptor.
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