These data support a role for QRFP as a modulator of nutrient intake in skeletal muscle.
The mammalian target of rapamycin (mTOR) pathway is widely regarded to be a central modulator of nutrient sensing and growth, which is known to adjust metabolism, increase autophagy, and reduce protein synthesis during CR (Johnson et al., 2013).
Here, we report that the osu1 mutants increase the sensitivity to both high C/low N and low C/high N, suggesting that the OSU1-encoded putative methyltransferase acts as a negative modulator of the C/N nutrient imbalance response.
DOI: http://dx.doi.org/10.7554/eLife.08698.011 One possible downstream effector of ROQUIN AMPK in Tfh cells is the mechanistic Target of Rapamycin (mTOR), a nutrient sensing kinase and modulator of cellular metabolism.
Vitamin D is a well-known nutrient that acts as a modulator of calcium homeostasis and the immune response [17], and the vitamin D receptor (VDR) is expressed in several types of immune cells, including monocytes, macrophages, dendritic cells (DCs), and effector/memory T cells [18] [20].
Sufficient nutrient and oxygen transport is a potent modulator of cell proliferation in in vitro tissue-engineered constructs.
Since mTOR is an important modulator of insulin-mediated glucose metabolism, rapamycin may exert adverse effects on the absorption of nutrients [ 25].
Vitamin D, a fat-soluble nutrient, is a secosteroid hormone which is widely recognized as a modulator of calcium absorption and bone health and further regulates neuromuscular function, cellular differentiation, insulin secretion, and blood pressure., Vitamin D also plays an important role in immune regulation through interactions between 1,25-dihydroxyvitamin D and vitamin D receptors (VDRs ).
The placenta-specific paternally expressed imprinted gene IGF2, which is a major modulator of placental and fetal growth [ 41], acts in the placenta to directly control the supply of maternal nutrients to the fetus.
"Fibroblast Growth Factor 9 Is a Novel Modulator of Negative Affect," from PNAS Depression is notoriously tough to handle pharmaceutically.
lncRNA-ROR is a modulator of cell reprogramming and pluripotency.
