Sentence examples for modulator of mitochondrial from inspiring English sources

Nitric oxide (NO) formed under inflammatory and hypoxic conditions is an important modulator of mitochondrial function.

This evidence supports the notion that mitochondrial superoxide is an important modulator of mitochondrial function, with even slightly elevated superoxide levels suppressing metabolism and extending lifespan and vice versa.

In a recent genome-wide RNAi screen of Drosophila melanogaster, HDAC6 was identified as a modulator of mitochondrial function, suggesting not only that it may exert a major influence on mitochondrial trafficking, but also that it may have a profound effect on overall mitochondrial function [27].

mTORC1 is a major positive modulator of mitochondrial metabolism and biogenesis (reviewed in Ref. 7).

Bcl-2 is a known modulator of mitochondrial OS and its absence is associated with increased OS state.

Thus parkin may be both a target of RNS signalling and a modulator of mitochondrial ROS generation.

Although all offspring inherit the mutation, often only some family members will develop the disease [30], which emphasizes the importance of nuclear genetic, epigenetic or environmental factors as phenotypical modulators of mitochondrial disorders.

Therefore, our focus in this respect was to look for correlations of vitality score with mitochondrial respiration and glycolysis parameters, by using well-defined modulators of mitochondrial respiration (oligomycin, FCCP and antimycin A; see below and Figure 1).

Proteins from the Bcl-2 family are considered as central modulators of mitochondrial apoptosis [ 66- 68], but other proteins that are not directly related to BCL-2 can induce or suppress mitochondrial outer membrane permeabilization (MOMP) as well.

This system is based on a pharmacological profiling approach that makes use of four added pharmaceutical modulators of mitochondrial electron transport chain fluxes, as described previously [ 12] and in Figure Supplemental S1 with representative OCR and ECAR profiles.

In order to evaluate whether TiO2-NP affected mitochondrial function, the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) (Supplementary Figure S1B) were measured in HaCaT cells exposed sequentially to modulators of mitochondrial activity (oligomycin, FCCP and Rotenone) in the presence of different concentrations of TiO2-NP for 24 h.