Sentence examples for modulator of insulin from inspiring English sources

Herein, we discuss evidence implicating REDD1 as a key modulator of insulin action and metabolic function, including its potential contribution to mitochondrial biology and pancreatic islet function.

Pancreatic beta-cells contain specific, high-affinity receptors for S-28, and it is plausible that this peptide is a physiological modulator of insulin secretion.

Here we show that DMPK itself is a positive modulator of insulin action.

Our experiments do not distinguish whether MISC-1 has effects on secretion of only DAF-28 or if it is a more general modulator of insulin secretion.

We hypothesized that forced expression of a negative modulator of insulin signaling would de-repress G6Pase-Luc reporter activity in the presence of insulin (Figure 1A).

OPN is novel participant in the early pathogenesis of diet-induced insulin resistance and a modulator of insulin target tissue biology.

Although pregnancy-associated plasma protein-A (PAPP-A), a modulator of insulin-like growth factor (IGF) activity through its cleavage of IGF-binding protein (IGFBP -4 and -5, has been known for more than two decades, knowledge about IGFBP -4in andhitecture is still incomplete.

Since mTOR is an important modulator of insulin-mediated glucose metabolism, rapamycin may exert adverse effects on the absorption of nutrients [ 25].

Furthermore, HMGA1 influences the expression of insulin growth factor-binding protein (IGFBP) and thus acts as a modulator of insulin-like growth factor I (IGF-I) activity [ 30], a gene which has been reported to be involved in bone growth, tibia length, body height, and body size in both humans and animals [ 31- 35].

Finding negative modulators of insulin signaling is therefore of enormous scientific and therapeutic importance.

These findings cumulatively suggest that quantitative changes in sphingolipids can be potentially relevant modulators of insulin action.