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The cytokine TGF-beta1 is a key modulator of immune responses that is increased in the brain in AD.
T cell immunoglobulin mucin 3 (TIM-3) is a modulator of immune responses expressed on subgroups of T and innate immune cells.
Setting: 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a potent modulator of immune responses and may be beneficial in the treatment of tuberculosis.
Tumor necrosis factor-alpha (TNF-alpha) is an important inflammatory cytokine and modulator of immune responses.
For example, agonistic or modulator of immune system (high risk) mAbs starting dose should be considered differently from antagonist antibodies.
Taken together, our present observations together with previously published data, support the hypothesis that endogenous morphine represents a modulator of immune cell activity.
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CD4+CD25high regulatory T cells (Treg) are essential modulators of immune responses, including down-modulation of immune response to pathogens, allergens, cancer cells and self-antigens.
Initially investigators believed that interleukins were made chiefly by leukocytes (white blood cells) to act primarily on other leukocytes, and for this reason they named them interleukins, meaning "between leukocytes". Because leukocytes are involved in mounting immune responses, interleukins were thought to function only as modulators of immune functions.
Cytokines are important modulators of immune response pathways [7], [18, 19].
Interestingly, a select few miRNAs were also predicted to be important modulators of immune function.
We demonstrate that cancer associated fibroblasts are key modulators of immune polarization in the tumor microenvironment of a 4T1 murine model of metastatic breast cancer.
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