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We first explored the potential function of RhoB as a modulator of endothelial cell migration.
The role of miR-21 as a modulator of endothelial cell organization into tubes was next evaluated.
Recent work also implicated S1P as a modulator of endothelial cell migration [13], [14], and angiogenesis in non-human non-reproductive tissues [15].
In other words, we demonstrate that EPC-CM is capable of inducing a change in endothelial phenotype towards increase sensitivity for PDGF, rending this receptor potentially an effective modulator of endothelial function in the process of angiogenesis.
Furthermore, SIRT1 is a critical modulator of endothelial angiogenic functions.
Sirt1 acts as a critical modulator of endothelial angiogenic functions.
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Two important modulators of endothelial cell function produced by 4T1 cells are vascular endothelial growth factor C (Vegfc) and angiopoietin 2 (Agpt2).
In a small exploratory study, we previously demonstrated that levels of modulators of endothelial permeability, such as VEGF-A and Ang-2 were altered in patients with FN that developed septic shock [ 22, 23].
Moreover, IGF-1 upregulates the expression of modulators of endothelial cell function such as VEGF, MT1-MMP, and MMP2; this regulation requires signalling through the IGF-1 receptor via both the PI3 kinase and MAP kinase pathways (Miele et al, 2000; Grzmil et al, 2004; Zhang et al, 2004).
The downregulation of Jagged1 and Notch3, key modulators of endothelial-perivascular interaction, observed in diabetes support this assertion.
FFP also contains high concentrations of albumin, which is a potential modulator of the endothelial glycocalyx and is possible that FFP acts by replacing albumin lost following haemorrhage [9 12].
More suggestions(15)
modulator of Munc18-syntaxin1
modulator of transcriptional
modulator of asynchronous
modulator of mitochondrial
modulator of 1st
modulator of IgE-mediated
modulator of β-catenin·Tcf-4
modulator of β
modulator of sexual
modulator of Negative
modulator of immune
modulator of IL7-dependent
modulator of many
modulator of β-catenin
modulator of focal
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