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Telintra, although designed to be a modulator of drug resistance through preferential inhibition of GSTpi ….
Transcripts for rpoH and other transcripts within its regulon, as defined in N. gonorrhoeae [66] were increased, including: NMB0977, a putative modulator of drug activity, secY, and the protein folding chaperones: grpE and groES.
Growth rate has been considered as an important modulator of drug activity in bacterial biofilms.
Among the genes uniquely found in clinical V. metoecus is a putative mdaB (modulator of drug activity B) gene.
Our two independent and complementary approaches identified EGFR as a potential SMARCE1 target gene and modulator of drug resistance.
It is implicated in proliferation, apoptosis and invasion and is considered to be an important modulator of drug resistance in different tumor systems.
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However, they may also exert biological activity as modulators of drug absorption and metabolism or as atypical active pharmaceutical ingredients.
Modulators of drug resistance would clearly have the benefit for the treatment of multidrug resistant strains for which the majority of therapeutic antibiotics have no further clinical use.
Several RNAi studies conducted with human tumor cell lines, using synthetic siRNAs/shRNAs targeting defined gene families or genomic-wide libraries, have identified modulators of drug sensitivity [ 3- 6].
Several RNAi studies performed in human tumor cell lines using synthetic small interfering RNAs (siRNAs) or vector-based short hairpin RNAs (shRNAs) targeting defined gene families or genome-wide libraries have identified modulators of drug sensitivity [ 27- 33].
Given that ghrelin and GLP-1 are fairly new modulators of drug-induced reward the involvement of these appetite-regulating peptides in reward and addiction processes are reviewed in this leading article.
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