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We go on to show that ARRB1 acts as a modulator of cellular metabolism that facilitates glucose uptake and glycolysis and that, through modulation of TCA cycle metabolites, it induces HIF1A stabilisation under normoxic conditions, a process named pseudohypoxia.
These emerging evidences establish that the ECM is not just a passive structural support as previously thought, but is rather an active modulator of cellular behaviors contributing to disease progression when negatively perturbed.
In addition, SDF-1 was found to function as both a chemoattractant and as a modulator of cellular growth/survival (Naiyer et al., 1999; Cashman et al., 2002; Liu et al., 2011).
Support stiffness is also increasingly discussed as a modulator of cellular phenotype.
However, it has also been recognized as a multifunctional modulator of cellular behavior [ 1, 2].
NAD(H) is considered a key modulator of cellular energy metabolism [ 53, 54].
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Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behaviour.
In vitro studies have identified nanoscale features as potent modulators of cellular behavior through the onset of focal adhesion formation.
Dendritic cells (DCs) are key antigen-presenting cells (APCs) that act as central modulators of cellular immune responses.
Stress response proteins can play integral roles as modulators of cellular function and can be involved in mechanisms that are important to immune function.
The c-ABL non-receptor tyrosine kinase and the p53 tumor suppressor protein are pivotal modulators of cellular responses to DNA damage.
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modulator of hippocampal
modulator of Munc18-syntaxin1
modulator of transcriptional
modulator of asynchronous
modulator of 1st
modulator of mitochondrial
modulator of IgE-mediated
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modulator of β
modulator of sexual
modulator of Negative
modulator of immune
modulator of IL7-dependent
modulator of endothelial
modulator of many
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