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Boucas, J. et al. Label-Free Protein-RNA interactome analysis identifies khsrp signaling downstream of the p38/Mk2 kinase complex as a critical modulator of cell cycle progression.
Moreover, in the same output file, CASP4 was also found as a modulator of cell death induced by Bortezomib and a host factor affecting C. burnetii growth.
Sufficient nutrient and oxygen transport is a potent modulator of cell proliferation in in vitro tissue-engineered constructs.
Encoded by the first candidate tumour suppressor gene it has emerged a versatile and context-dependent modulator of cell behaviour.
Collectively, our experimental results, corroborated with patient data, establish the miR-564/AKT2-GNA12-GYS1-SRF network as a key modulator of cell proliferation, EMT migration and invasion in breast cancer.
Intracellular pH, an important modulator of cell function, is regulated by plasmalemmal proteins that transport H+, or its equivalent, into or out of the cell.
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Our data is consistent with the observations in Alzheimer's and Parkinson's disease that seeding with native protein is much more efficient than synthetic seeds,39 reflecting the likelihood that additional properties present in patient-derived CSF beyond the mHTT protein can also be captured as a modulator of cell-to-cell propagation, including the presence of neuroinflammatory cytokines.
The regulation of the Nucleoredoxin-like genes involves a CRX responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity.
Notch-1, a breast oncogene, is a modulator of cell-fate decisions (Politi et al, 2004).
In addition to their metalloproteinase domain, ADAMs contain a disintegrin domain as a modulator of cell-cell and cell-matrix interactions [ 15].
This signalling pathway has been identified as a modulator of cell-cycle progression through molecular events by which RhoA/ROCK/LIMK (LIM domain kinase) inhibition led to stress fibre disassembly, a decrease in ERK1/2 (extracellular-signal-regulated kinase 1/2) phosphorylation and subsequent cyclin D inhibition (Walker and Assoian, 2005).
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