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Physiologic variations in perfusate composition have been identified as a new and important modulator of cardiac conduction velocity (CV), particularly when gap junctions (GJ) are reduced.
Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.
Lodder, EM, Scicluna, BP, Milano, A, Sun, AY, Tang, H, Remme, CA, Moerland, PD, Tanck, MWT, Pitt, GS, Marchuk, DA, and Bezzina, CR. "Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction". Plos Genetics 8, no.
Prall and coworkers [16] showed that Smad1 ablation in the SHF enhances cell proliferation, and thus it has been proposed as a negative modulator of cardiac progenitors proliferation.
Thus, the integrin/ILK pathway emerges as a key modulator of cardiac homeostasis and aging.
Our data demonstrate that the β1-integrin/ILK pathway is a critical genetic modulator of cardiac and organismal aging.
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BCL2, which is involved in a number of cancers including melanoma, breast carcinomas and etc., was recognized as important modulators of cardiac myocyte apoptosis.
Yet, as in many other tissues [ 4], the role of endogenous modulators of cardiac inflammation, such as cTMs, is not fully understood.
Thus it appears highly likely that these sphingolipid molecules and their analogs have the potential to act as therapeutic modulators of cardiac responses to myocardial injury.
Indeed, the transcription factors have been found to drive the cardiac processes via regulating the gene expression of specific miRs, which act as post-transcriptional modulators of cardiac gene expression [ 13, 84].
Therefore, εPKC appears to be a positive modulator of compensatory cardiac hypertrophy in this mouse model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com