Hosoda, H. et al. CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription.
In our study, lovastatin was used as a pharmacological modulator of CAV1.
FTY720 (fingolimod) is an oral modulator of S1P (sphingosine-1 phosphate) receptors.
Isaacs, J. T. et al. Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment.
Limited glucose bioavailability is a key feature of the tumor microenvironment16, 17 that we tested as a potential modulator of MCT1 and CD147 expression.
However, Yoda1 acted as a gating modulator of PIEZO1 (Supplementary Fig. 5a,b) by slowing down both the current rise time, inactivation and deactivation time constants49.
Performing a high-throughput screening of a large collection of human microRNA mimics, we identified miR-149-3p miR-149-3p miR-149-3passcriptional modulator of DAB2IP.
We thus used a small molecule modulator of PIEZO1 activity, Yoda1, to promote conformational states of the PIEZO1 that may enter a voltage-gated mode.
Finally, being a transient and temporally controlled phenomenon that occurs under the influence of a pharmacological modulator of CAV1, normalization of the cellular distribution of HER2 including receptor-mediated internalization of the antibody bound to it would occur once the transient in vivo effect of the CAV1 modulator has worn out.
Despite being an effective modulator of CAV1 in our experiments, lovastatin is a lactone pro-drug that is plagued by poor oral bioavailability ( < 5%) owing to its lipophilic nature57.
Komatsu, M., Jepson S., Arango, M. E., Carothers Carraway, C. A. & Carraway, K. MUC4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor.
