Sentence examples for modulator of autophagy from inspiring English sources

Specifically, glutamine can positively modulate autophagy through glutaminolysis via the production of ammonia, a positive modulator of autophagy (Table S1I).

Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.

A well-documented mechanism to induce autophagy is by inhibition of mTOR, a negative modulator of autophagy and rapamycin (sirolimus) is a commonly used inhibitor of mTOR.

During starvation the transcriptional activation of catabolic processes is induced by the nuclear translocation and consequent activation of transcription factor EB (TFEB), a master modulator of autophagy and lysosomal biogenesis.

Hence, PRKCD is probably a negative modulator of autophagy.

Thus, CHOP is an ASPP2 overexpression-induced modulator of autophagy.

OVs can induce autophagy and immunogenic cancer cell death which may be potentiated by co-administration with autophagy modulators as modulation of autophagy may enhance tumor immunogenecity [ 29].

Nine entities identified as dual modulators of autophagy did not appear to exhibit a dominant direction of autophagy modulation in the analysis— BAX, BCL2, BCL2L1, BCL2L11, FBXL20, MAPK14, MYC, PRKCD, and TP53 (Table S1C).

Fleming, A., Noda, T., Yoshimori, T. & Rubinsztein, D. C. Chemical modulators of autophagy as biological probes and potential therapeutics.

To develop a screening assay for chemical modulators of autophagy, human breast cancer MCF-7 cells were stably transfected with a plasmid for expression of LC3 linked at its N-terminus to EGFP (Fig. 1a).

Following pipeline validation, using commonly used drug modulators of autophagy, we screened the Prestwick Chemical Library (http://www.prestwickchemical.com), consisting of 1,120 US Food and Drug Administration (FDA -approved compounds, FDA -approveds of autophagy.