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To investigate the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding for angiopoietin-2 (anGPT2), autochthonousous modulator of angiogenesis during pregnancy.
To explore the role of Akt1, a principle modulator of angiogenesis, in ovarian graft reception and to investigate whether Akt1 deficiency can alter ovarian graft reception.
Tgfbeta1 is also a well-established modulator of angiogenesis [19].
HRG has been shown to act as a positive modulator of angiogenesis by inhibiting the antiangiogenic effect of TSP1 [20].
Then using in vitro angiogenic assays, we observed that miR-21 acts as a negative modulator of angiogenesis.
Because FAK is a major modulator of angiogenesis, we examined the status of FAK in transfected meningioma cells along with irradiation.
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In vitro experiments, using human microvascular endothelial cells, demonstrated that tick saliva is a negative modulator of angiogenesis-dependent wound healing and tissue repair [ 55].
Vascular Endothelial Growth Factor (VEGF) pathway has emerged as one of the most important positive modulators of Angiogenesis, a central process implicated in tumour growth and metastatic dissemination.
Interestingly, γ-secretase cleaves several proteins including Notch, E-cadherin, CD44 and ErbB-4 (erythroblastic leukemia viral oncogene homolog 4), which are important modulators of angiogenesis.
This work proposes the use of CS technology to engineer cellular constructs based on human keratinocytes (hKC), key players in wound re-epithelialization, dermal fibroblasts (hDFb), responsible for ECM remodelling, and dermal microvascular endothelial cells (hDMEC), part of the dermal vascular network and modulators of angiogenesis.
The fact that a large number of essential modulators of angiogenesis participate in CAM vascular development suggests that genes previously not associated with blood vessel formation might be present in the gene signatures we have described.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com