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Since catalytically active LOX, whose levels could plausibly differ between vascular beds, may be able to act as a chemoattractant and a modulator of adhesion and the invasiveness of tumor cells [17], [20], we investigated whether BAPN administration would alter the anatomical pattern of metastases.
Based on characteristics of the gene discussed below we have named it sma (SAP domain-containing modulator of adhesion).
DUF1542 repeats are found in many Gram-positive cell surface adhesins, such as MabA, a modulator of adhesion and biofilm formation, from Lactobacillus rhamnosus GG [ 60].
NO is an important modulator of adhesion molecule expression in both acute and chronic inflammatory states, and may influence the course of IBD.
NO is an important modulator of adhesion molecule expression in both acute and chronic inflammatory states and may influence the course of chronic inflammation.
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The peptides were studied for their possible use as biomimetic materials due to their auto-assembling properties and to the presence, in two of them, of the RGD sequence, an active modulator of cell adhesion.
As a recognized modulator of cell adhesion and motility for mesenchymal cells, increased versican expression in malignant derivatives appears to contribute towards a more aggressive phenotype [ 20, 21].
Chga, a member of the granin family of neuroendocrine secretory proteins, is located in secretory vesicles of neurons and neuroendocrine cells with a suggested role as a modulator of cell adhesion.
However, the phosphorylation of paxillin at Tyr decreased in FRNK cells as compared with pWZL cells, consistent with a model of FAK as an upstream modulator of focal adhesion components phosphorylation (Ruest et al, 2001).
Baptiste et al. [ 28] showed that galectin-3 was a powerful modulator of cell adhesion and spread in breast carcinoma cells and that the exogenous addition of recombinant galectin-3 promoted the growth of galectin-3 null galectin-3 null
More precisely, it is a soluble, secreted protein that can act as an autocrine and paracrine factor, as well as a modulator of cell adhesion through its interaction with integrins and CD44.
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