Sentence examples for modulator of a from inspiring English sources

The β-adrenergic pathway is an upstream modulator of a multifunctional signaling pathway implying that unwanted effects associated with its modulation could be bypassed by treating myosin directly.

It has long been recognized that the endogenous purine nucleoside adenosine is a potent modulator of a large number of neurological functions.

Since α-actinin is a modulator of a variety of signalling pathways and of cytoskeletal functions, its targeting by Opc may enable bacteria to survive/translocate across endothelial barriers.

mRNA levels of calcineurin, a modulator of a number of key Ca2+ signalling pathways in neurons, were significantly increased on exposure to higher concentrations of lead, with peak expression occurring at 100 μM (Fig. 5E).

In particular, miR-7 emerged as a critical modulator of a regulatory network for EGFR signaling in lung cancer cells, with the ability of coordinately downregulating the expression of several members of the EGFR signaling cascade [ 161].

63 Like other statins, pitavastatin appears to be a modulator of a variety of vascular and inflammatory markers via inhibition of mRNA expression of interleukin-8, endothelin-1, and plasminogen activator inhibitor-1, along with increased expression of endothelial nitric oxide synthase and thrombomodulin in human umbilical vein endothelial cells.

It is already recognized that these steroids can act as modulators of a variety of ion channels (Covey, 2009).

The classical paradigm is to predict the modulators of a given target, considering each target independently from other proteins.

In spite of their traditional role in allergic disorders and innate immunity, MCs have lately emerged as versatile modulators of a variety of physiologic and pathologic processes.

Furthermore, p21WAF1 is a modulator of apoptosis in a number of systems [ 34- 36].

These results emphasize the influence of nanotopography as a modulator of cellular responses to a cytotoxic agent.