Sentence examples for modulator of Negative from inspiring English sources

"Fibroblast Growth Factor 9 Is a Novel Modulator of Negative Affect," from PNAS Depression is notoriously tough to handle pharmaceutically.

Since PLK-1 is a negative modulator of p53, inhibition of PLK-1 would relieve the negative regulation on wild-type p53 and potentially restore its transactivation and apoptotic functions.

This indicates that a variety of negative modulators of IR cooperate to inactivate IR.

One potential mechanism contributing to pathway activity might be loss of negative modulators of WNT signaling [ 48], as decreased expression of sFRP1 is well documented in human breast cancer [ 10, 11, 29].

The strong negative effect of apigenin on STAT3 phosphorylation in TF1 cells can be explained by increase of expression and activity of LMWPTP, one of negative modulators of STATs, as well as the strong inhibition of SHP-2; LMWPTP activity was about 4-fold (385±94%), 2-fold (198±28%), and 10-fold higher (1083±47%) in the presence of 25, 50, or 100  μM apigenin, respectively.

Like RRAGA/B and RRAGC/D, GNAI3 should be considered a negative modulator of autophagy, even though there is only a single reference to it as a negative modulator.

These data suggest that CAST may be a negative modulator of BMD and a downstream target of BMP2 in modulating CAST mRNA expression of osteoblasts.

PLK-1 is a negative modulator of p53 activity but has not been shown to affect its levels [32].

Controversy remains over whether hepatocyte growth factor (HGF) is a positive or negative modulator of BMP-induced osteogenesis.

A well-documented mechanism to induce autophagy is by inhibition of mTOR, a negative modulator of autophagy and rapamycin (sirolimus) is a commonly used inhibitor of mTOR.

Pregnenolone (1 and 2 mg/kg i.p ., a negative modulator of GABAA pretreatment significantly reversed the protective effect of progesterone on behavioral and biochemical parameters.