Res is a modulator of CYP1B1 [75, 75, 103] and an inducer of quinone reductase (Fig. 2) [75, 104].
Moreover, the transcription factor Lhx8 and the modulator of 5-HT1A-mediated neurotransmitter release, Rgs4, exhibit significant higher expression in ventral hindbrain, compared to midbrain and are target genes of Sim1.
Fig. 6A shows qRT-PCR analysis and relative mRNA expression of the transcription factors Brn3.2 and Lhx8, as well as for RGS4, a regulator of G protein signalling and modulator of 5-HT1A-mediated neurotransmitter release, in mouse E11.5 ventral hindbrain tissue, compared to ventral midbrain.
Since SIL1 is a modulator of HSPA5, SIL1 mutations are likely to disturb HSPA5 function during corticogenesis.
The discovery of DBC1 as a modulator of SIRT1, HDAC3, SUV39H1 and several nuclear receptors raises the possibility that DBC1 may be a master regulator of the interconnection between metabolism, and epigenetics.
Cells (1 × 10) were preincubated with and without 10 or 25 μ M estramustine (modulator of ABCA2), 3 μ M mitoxantrone was added and the cells were incubated for 60 min at 37°C, 5% CO2.
DOI: http://dx.doi.org/10.7554/eLife.01557.033 The following dataset was generated: Chen P, 2013, Hdac6 is a stem-cell specific modulator of Tip60-p400 function, GSE42329 ; http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi token=tvmhfusekaaakpy&acc=GSE42329, Publicly available at NCBI GEO.
Compounds were shown to act as state-dependent modulators of Nav1.3, Nav1.4 and Nav1.7 with IC50 values in the lower micromolar range for the open-inactivated state of the channels.
Importantly, the detected alterations in the APC/CTNNB1 signaling pathway may also influence mTOR activity since GSK3B, an important member of the APC/CTNNB1 signaling pathway, is one of many modulators of TSC1 [41], [41].
Furthermore, data describing potential modulators of mRNA expression of Fan1, Mre11a, and telomere length, in the context of CKD progression, are unavailable.
