Although it is not consistent with the typical cationic and hydrophobic properties that define HDPs, OPN has been reported to play crucial roles as an immune modulator, being involved with chemotactic properties to recruit cells to inflammatory sites, with mediating cell activation and cytokine production and with wound healing [ 12, 74, 75].
The neuronal c-Jun N-terminal kinase (jnk-1) is a positive modulator of DAF-16 and is involved in regulating longevity.
However, because Lyn is an important modulator of erythropoiesis and Hck is involved in the survival of myeloid cells and B lymphocytes, it has been proposed that nilotinib may have a more favorable adverse event profile with regard to myelosuppression.
Studies indicated that KCMF1 is involved in regulating growth modulators [ 29].
AHRR is a feedback modulator by repressing AhR-dependent gene expression and is involved in the regulation of cell growth and differentiation [ 25].
GABAA gamma2 is one subunit of GABAA receptor complex that is involved in binding of GABAA receptor modulators such as benzodiazepines [57]; it is a representative of GABA system genes.
In addition, our study suggests that mTOR signaling, a key modulator of geroconversion, aging and age-related disease [ 44, 45], is involved in fibroblast aging.
EC is involved in the immune and inflammatory response, coagulation, growth regulation, production of extracellular matrix components, and is a modulator of blood flow and blood vessel tone.
BCL2, which is involved in a number of cancers including melanoma, breast carcinomas and etc., was recognized as important modulators of cardiac myocyte apoptosis.
PTGDS is actively produced in a variety of tissues and is involved in numerous physiological and pathological functions, such as vasodilatation, inhibition of platelet aggregation and nitric oxide release; moreover, it is a potent endogenous nociceptive modulator [9].
