Sentence examples for modulator has shown from inspiring English sources

Our previous work with raloxifene, a selective estrogen receptor modulator, has shown that the drug, and to a greater extent its micellar formulation, has a significant suppressive effect on NF-κB, an essential immune-regulator.

Toremifene, a second-generation selective receptor modulator, has shown promise for the management of ADT-associated lipid changes, but its effect on cardiovascular outcomes has not yet been evaluated.

This orally available S1P-receptor modulator has shown striking efficacy in experimental allergic encephalomyelitis models of multiple sclerosis (Brinkmann et al., 2002; Fujino et al., 2003; Webb et al., 2004 Kataoka et al., 2005; Balatoni et al., 2007) and recent results from phase II trials with RRMS patients are promising (Kappos et al., 2006).

Blockade of these receptors, either by the use of antagonists or negative allosteric modulators, has shown great promise in the treatment of PD and related dyskinetic side effects in rodent and primate models of PD (Rylander et al., 2009; Yamamoto and Soghomonian, 2009; Johnston et al., 2010).

Although these immune checkpoint modulators have shown acceptable safety profiles based on the available clinical data outside of China, autoimmune diseases, including fetal cases of immune-mediated pneumonitis, are among the risks associated with this new class of medicines.

Promising research has shown that allosteric modulators of GPCRs can be used to treat addiction by altering the affinity of the GPCR to its ligand or impacting its downstream signaling responses [ 72].

Increasing evidence has shown that platelets function as an immune modulator in several inflammation-associated processes [ 32].

13, 23 Increasing evidence has shown that fibroblasts are among the most crucial components of the tumor microenvironment and are prominent modulators of cancer progression.

"Modulator pheromones have shown us, for example, when women are exposed to certain male underarm compounds, they become less tense, more relaxed," he said.

Drugs with entirely novel mechanisms, such as the gap junction modulator rotigaptide, have shown efficacy in ventricular arrhythmias and have potential for atrial arrhythmias as well.

Riluzole, an ion channel modulator, has been shown to demonstrate by estrogen receptor stress an inhibition of DNA synthesis and apoptosis in certain cell lines [33].