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Here, we reported a novel engineering strategy based on CcpA molecular modulation to overcome the defect.
CA9 modulation to overcome anti-VEGF therapy resistance may be a potential therapeutic area of investigation in the future.
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Pulse position modulation (PPM) is a power-efficient modulation scheme to overcome this problem.
As 5-FU-based chemotherapy is still the main treatment option for advanced metastatic CRC, it is important that a miR-129 restoration approach may offer a new modulation strategy to overcome chemoresistance.
Adaptive modulation is exploited to overcome the performance enhancement limitation in source rate control schemes employing fixed modulation.
A novel method of asynchronous (switching) modulation is presented to overcome laser-induced non-PR background effects, which limit or even obscure the complex (phase) PR response.
The MOEMS modulator was designed to overcome the inherent low frequency noise of solid-state photo-detectors by means of a previously reported modulation technique, named IHOS (Integrated Heterodyne Optical System).
Other non-coherent modulation schemes have been proposed to overcome the decrease of the data rate and to improve the system performance.
Biologically, AR signaling in TNBC which not only interacts with a network of key pathways, involving PI3K/AKT/mTOR, cell cycle, and DNA damage repair pathways, but mediates pivotal processes of tumor initiation and immunogenic modulation, may present an opportunity to overcome the insensitivity of single AR-targeted therapy.
Thus, the increase of PDL-2 expression could be an attempt to inhibit the inflammatory response from arthritis, but, in this case the parasite immune modulation is just not enough to overcome the intense inflammatory response of the experimental RA.
The steric modulations further assist the pendent groups to overcome the torsional barriers presenting a larger accessible potential energy surface [ 47].
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