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Endothelium is crucial to the modulation of vessel tone and to the control of platelet adhesion and aggregation, two key factors in the initiation and development of atherosclerosis [7].
The role of platelets in tumor angiogenesis and the modulation of vessel permeability are well established, whereas their effect on the tumor microenvironment is still undefined.
At the level of the vessel wall, ROS may affect vascular resistance either by direct modulation of vessel tone or by affecting vascular remodelling [ 92].
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Detailed knowledge about differences and similarities of gene regulation during normal and pathological angiogenesis is essential to design new drugs aiming at specific modulation of blood vessel growth and function.
Utilization of NO as an immobilizing material resulted in the modulation of blood vessel tone, inhibition of platelet activation, and leucocyte adhesion and SMC hyperplasia [ 65].
Likewise, Strieth and coauthors have reported that SMF affects the vascular and blood flow [ 30] and Okano and coworkers have investigated the modulation of blood vessels by magnetic fields [ 10, 31- 33]. 1 Annotated network diagrams are provided in Additional file 1.
SBP variability is regarded an index of sympathetic modulation of peripheral resistance vessels [ 33].
Intracranial aneurysm (IA) is one of the most lethal forms of cerebrovascular diseases characterized by endothelial dysfunction, vascular smooth muscle cell phenotypic modulation, inflammation and consequently loss of vessel cells and extracellular matrix degradation.
Some authors have suggested that the PWS is related to disorders of neural crest cells [ 15, 16]; ultrastructural and immunohistochemical studies have demonstrated the absence of perivascular nerves in PWS [ 14, 17] favouring the hypothesis of an alteration of autonomic nerves surrounding blood vessels which causes deficits of vessel caliber modulation [ 14, 18].
However, less is known regarding the role and interaction among alcohol consumption, immune modulation of tumor growth, blood vessel formation (i.e., angiogenesis), metastasis, and survival.
EMP1 may be involved in the modulation of intercellular adhesion in vessels after endothelial cell activation and participate in the mobility and sprouting of vessels in the GT.
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