Concepts based on the modulation of various device parameters have been explored earlier.
PMA itself has both oncogenic and anti-tumorigenic properties by direct or indirect modulation of various cellular targets (Griner and Kazanietz, 2007).
Gene regulation studies indicated the transcriptional modulation of various genes involved in Zn, macro- and micro nutrient homeostasis as well as hormone regulation.
Ran, a small Ras-like GTP-binding nuclear protein, plays a key role in modulation of various cellular signaling events including the cell cycle.
Some cells may undergo irreversible alteration at the genome level, some may exhibit changes in their gene expression pattern, while others may incur neither genetic reconstruction nor gene expression changes, but only modulation of various fluxes by changing nutrient/metabolite concentrations and enzyme activities.
Studies of Tβ4 in multiple tissue models showed modulation of various inflammatory cytokines.
The cytokine antibody array was performed using conditioned media to check the possible modulation of various cytokine levels in MMP-2siRNA treatments (data not shown).
Many viruses have evolved strategies to neutralize TNF by direct binding and inhibition of the ligand or its receptor or modulation of various downstream signaling events [14].
More recently, we and others have shown that LA exhibits a non-redox anti-inflammatory role [7], [9], [10], [11], probably via modulation of various signaling cascades that mediate these processes.
In conclusion, the results of this study demonstrated that central Ang II potentiated amyloidogenesis in vivo, through modulation of various components of the APP processing pathway; these actions could be completely abolished by concomitant ICV infusion of losartan.
While the NMDA receptor is the primary receptor in gating the memory processes, other neurotransmitter systems can be also important for the regulation and modulation of various aspects of memory function, including motivation, attention, emotion, etc [36] [38].
