Sentence examples for modulation of upstream from inspiring English sources

In particular, it is not known if pathogens inhibit autophagy by modulation of upstream regulatory pathways.

We propose that cholesterol "trapped" in the LE/LY is accessible for removal in response to modulation of upstream steps along the endosomal pathway, in our case endosomal recycling.

To explain the frequent occurrence of promoter methylation in sporadic CLL, one may postulate DAPK1 silencing due to modulation of upstream signals.

Additionally, the analysis here provides insight into understanding to what extent control or temporal modulation of upstream signals may be propagated through multiple pathways and how this affects the manner in which pathways interact with one another.

This study provides clear and substantial evidence that brewers' rice offers great potential against colorectal cancer through the inhibition of colon carcinogenesis by the modulation of upstream and downstream components in the Wnt signaling pathway.

Activated Akt regulates several proteins that are involved in cell migration and invasion, either by direct phosphorylation of these proteins or by modulation of their upstream regulators [ 52].

Therefore it is important to establish whether modulation of the upstream or downstream targets of the PKC, either inhibition or restoration of activity, would be sufficient to change the course of the malignancy.

The results show that the modulation of the flow upstream of the flame produces strong variations in the flame's area and also intense noise emission.

Specifically, at low approach velocities (5 m/s), the effect of upstream flow modulation is to improve flame stability as evidenced by lower flame blowoff equivalence ratios for all three types of flame holders considered.

We note that the sleep-EEG profile of D1 antagonism is very similar to that of GABAa (gamma-aminobutyric acid) receptor modulators and suggest that D1 antagonism may alter the properties of the neuronal networks which generate delta and spindle, and K-complex EEG waveforms through the upstream modulation of GABAa receptor activity.

These studies [14], [16] successfully identified potential actions for propofol-mediated inhibitory signaling through modulation of MAPK/ERK1/2, which acts upstream of NF-κB signaling.