Sentence examples for modulation of underlying from inspiring English sources

In this work, we developed a computational framework for proposing associations between the ADRs of clinically approved drugs and the modulation of underlying biological pathways.

According to systems theory, although individual genes or environmental factors may be a critical component in the pathogenesis of a particular complex disease, it is ultimately the modulation of underlying pathways that the particular gene/environmental factor is a part of that determines the resultant phenotype.

To summarize the results obtained from these test samples, QD strain modulation of the underlying QW, which is deposited before the QDs, through either direct strain or indirect piezoelectric modulation, results in a broadened linewidth of the e1-hh1 transition and leads to larger oscillator strengths for the higher order QW transitions (e1-hh2, e1-hh3).

Instead, to give a realistic representation of our results, the rate constants themselves must presumably undergo slow changes via additional layers of extrinsic regulation [39], perhaps involving random low frequency modulation of the underlying burst size or frequency.

In conclusion, our studies uncover the novel miR-8/Ena regulatory axis of NMJ morphogenesis that involves the modulation of the underlying postsynaptic actin cytoskeleton, thereby expanding our knowledge of the diverse repertoire of microRNA regulation in synapse development.

Infections may contribute to the aetiologic pathway and/or be markers of underlying immune modulation.

We here investigated the dopaminergic modulation of network dynamics underlying basic motor performance, i.e. finger tapping, and higher motor control, i.e. internally and externally cued movement preparation and selection.

Combining fibrin network rheology with simultaneous confocal microscopy provided direct evidence of structural modulations underlying nonlinear viscoelasticity of compressed fibrin networks.

Each of these genes encodes either a receptor or a secreted protein, modulation of which may underlie the interactions between Wnt/β-catenin tumour cells and between the tumour and its microenvironment.

Identified molecular targets underlying modulation of brain excitability include both the inhibitory GABAA and the excitatory NMDA receptor.

However, the expression of μ-opioid receptors in the XII motor nucleus and also the mechanism underlying modulation of XII MNs by μ-opioids is controversial.