In contrast, intracellular accumulation of Lck was mediated by an independent Nef activity, involved the microtubule network and was insufficient for the modulation of the tested aspects of TCR signaling.
The circadian modulation of activity was tested on a subgroup of 57 mice (14 B6-WT, 16 B6-KO, 15 FVB-WT and 12 FVB-KO), while the test of direct social interaction with a female was conducted on a subgroup of the latter of 54 mice (12 B6-WT, 15 B6-KO, 15 FVB-WT and 12 FVB-KO).
Antigenic modulation of MLr as tested by trypan-blue exclusion and by chromium51 release does not lead to a measurable change in the expression of H-2K, H-2D, TL and Thy1.2 antigens.
There have previously been few attempts to test modulation of dopaminergic activity as a therapeutic option in hemispatial neglect, but the largest trial tested only four patients.
The Fluconazole antibiotic was used as the reference drug in the modulation of the commercial drug test.
To test if modulation of Sin1 is important for mTORC2 activity, we and others tested if Sin1 could be targeted for phosphorylation by Akt or S6K at either T86 and T398, or both sites, in adipocytes (Humphrey et al., 2013) or epithelial cells (Liu et al., 2013), respectively.
In addition to the efficacy endpoints, we assess the peripheral and central modulation of pain (quantitative sensory testing, QST, and conditioned pain modulation, CPM) in all the patients to explore the differences in pain processing induced by the EMDR intervention.
Given the role of SynI in the modulation of release dynamics, we tested whether the Q555X mutation can modify the E/I balance and excitability at the network level by differentially altering basal transmission and/or STP paradigms in excitatory and inhibitory synapses.
Thus, to evaluate the possibility that a C5a-triggered G-protein-independent signalling event was the target of TLR modulation, we tested the effect of TLR activation on the activity of C5L2.
Applying biomarkers in early clinical trials helps identify the most appropriate patients; provides proof of concept for target modulation; helps test the underlying hypothesis; informs the rational selection of dose and schedule; aids decision making, including key go/no go questions; and may explain or predict clinical outcomes.
