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This study directly demonstrates that autoreceptor-mediated inhibition of terminal dopamine release in caudate putamen is designed to provide a rapid, robust, yet short-lasting modulation of terminal dopamine release.
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Additionally, in RASSF9−/− keratinocytes there was a drastic down-modulation of terminal differentiation markers, which could be rescued by infection with a recombinant adenovirus, Adv/HA-RASSF9.
The motor neurons also up-regulate processes directly relating to membrane excitability and neural transmission, suggesting that the motor neurons change their synaptic strength, both pre-synaptically through modulation of axon terminals with increased machinery for acetylcholine release and post-synaptically through modulation of receptor channels as well as changed membrane excitability.
Anion effects on the C terminus were additive with anion modulation of β subunit/N terminal interactions.
We determined whether metformin induced a modulation of apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) overall and by insulin resistance status in a presurgical trial.
The role of this protein in regulating learning and memory, presumably via modulation of the postsynaptic terminal in the MB calyx, is novel, and the functional antagonism with dfmr intriguing.
Furthermore, modulation of earlier and terminal differentiation markers in OSCC-derived cells by over-expression and knock-down of S100A16 provided direct evidence that S100A16 functions as a differentiation promoting protein in OSCC (Fig. 4).
It could act directly to release the ATP lid either by displacing it or indirectly by modulation of the N-terminal sequence (β-strand 1 and α-helix 1) of the N-terminal domain that is intimately associated with the ATP lid.
Modulation of Hsp90 C-terminal function represents a promising therapeutic approach for the treatment of cancer and neurodegenerative diseases.
An important issue to outline is whether the observed effect of nitric oxide during cyclophosphamide-induced cystitis is exerted via modulation of afferent nerve terminals or by acting directly on the detrusor.
The LBD also contributes to the modulation of the N-terminal AF-1 through interdomain crosstalk so that both AF-1 and AF-2 domains can recruit a range of coregulatory proteins and act either individually or in a synergistic manner (Kobayashi et al. 2000; Métivier et al. 2001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com