Sentence examples for modulation of tau from inspiring English sources
Furthermore, PR-619 led to the stabilization of the microtubule network, possibly through the modulation of tau phosphorylation, and small tau deposits assembled near the MTOC.
In order to identify genes involved in modulation of tau phosphorylation, we developed a high content siRNA screening assay.
While chaperone modulation of tau is an emerging field, preventing tau aggregation directly with compounds that bind tau is much further developed.
In vitro, leptin treatment is reported to reduce Aβ levels in neurons by inhibiting β-secretase activity and to reduce tau phosphorylation through the modulation of tau kinases (Greco et al., 2008, 2009).
Therefore, although Tau neuron's firing activities were not location-specific and Tau sequences were not primarily driven by space, there was still a modulation of Tau neuron's firing activities by spatial experience and spatial trajectory.
Modulation of tau splicing using antisense oligonucleotides has been obtained in vitro using minigenes or neuronal cell lines (26– 28); however, there has been no report to date of their use in vivo.
Moreover, AST inhibited production of p53 and phosphorylation of tau by modulation of the Bcl-2/Bax ratio.
A couple of evidences support a role for the microtubule-binding domain in the modulation of the phosphorylation state of Tau proteins.
As the primary function of tau is modulation of cytoskeletal MT stability and function, and abnormal tau phosphorylation results in disruption of MT organization, we also investigated the effect of DAPK1 on MT organization.
The results presented in the current report demonstrate that modulation of the acetylation state of tau's KXGS motifs is the foundation of a dynamic relationship between HDAC6 and tau.
The strategy of γ-secretase modulation reduced tau protein in different genetic forms of AD, suggesting that this approach to reducing tau levels may be a useful therapeutic strategy in different forms of Alzheimer's disease.
