Modulation of TASK-3 (Kcnk9) potassium channels affect neurotransmitter release in thalamocortical centers and other sleep-related nuclei having the capacity to regulate arousal cycles and REM sleep changes associated with mood disorders and antidepressant action.
Modulation of TASK-2 by extracellular pH involves changes in open probability (Po) without affecting single-channel conductance [9], [21].
PPIs can be identified by GLMs sensitive to contextual modulation of task-related covariance.
The aim of current stimulation protocols is modulation of task-relevant regions of cortex.
The DLPFC is believed to exert its controlling influences through the top-down modulation of task-relevant information processing in, for example, the premotor and posterior parietal associative cortices (MacDonald et al. 2000; Koechlin et al. 2003).
To explore the task-related functional connectivity of the DLPFC region showing a modulation of task-related activation by anxiety with distal brain regions, we conducted psychophysiological interaction analyses (PPI; Friston et al., 1997).
Region sets were combined in order to cast as wide a net as possible in identifying regions that may contribute to the 2 most reliable features of the behavior (the task effect, and the modulation of the task effect by lexicality); also there was considerable overlap between the images.
Our results add a new network perspective to our understanding of the neural underpinnings of emotion regulation, and highlight that connectomic methods can play a valuable role in comprehensively investigating modulation of connectivity across task conditions.
Based on the above results, we hypothesized that white matter burden would mediate the relationship between modulation of activity and task performance.
Adding slope of activity resulted in a significant change in R (Table 3, Model 6), indicating that amyloid burden did not influence the relationship between modulation of activity and task performance.
