Sentence examples for modulation of surrogate from inspiring English sources

If the modulation of surrogate response biomarkers such as IEN can be validated as being correlated with a reduced cancer incidence in phase III trials, then prevention trials of the future might use IEN instead of cancer incidence as their main study endpoint.

To allow these trials to be rapid and efficient, the study outcome is modulation of a surrogate endpoint biomarker (SEB), that is, a molecular event assumed to be on the causal pathway between the chemopreventive agent and the desired reduction in cancer incidence.

Modulation of an individual surrogate response biomarker is likely to be dramatically influenced by agent, menopause status and baseline characteristics of the cohort (Table 1).

These data provide the first detailed evidence for the modulation of lipoprotein particles and other surrogates of vascular risk with IL-6R inhibition.

HRV measures provide information primarily on vagal modulation with the LF power spectrum reflecting both sympathetic and parasympathetic modulation and HF acting as a surrogate marker of parasympathetic modulation of the R-R intervals [ 12].

I assumed the role of surrogate mother.

Thus, how to choose sample points, how to build surrogate models, and how to evaluate the accuracy of surrogate models are key issues for surrogate modeling.

Surrogate outcomes that have not been fully evaluated may be used based on the concept of surrogate threshold effects [25].

It was that theme of surrogate parenting, surrogate fathers.

Thus, chemotherapeutic modulation of CAR expression could be studied as a surrogate biomarker for senescence response.

The chapter discusses that by design, human surrogate models of neuropathic pain involve a reversible modulation of the properties of the nociceptive system such as its acute plasticity (phase 2).