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The 5-HT1A receptors appear to play an important role in the serotonergic modulation of sleep and waking.
The time course of selegiline-induced wakefulness was shown to follow the time course of l-methamphetamine and l-amphetamine in brain, suggesting that these metabolites are responsible for the modulation of sleep architecture.
Indeed, even though a number of studies have found no difference in terms of the subjective sleep quality between naturally cycling women and OC users [ 73, 74], a modulation of sleep architecture by OC use has been shown [ 73- 77].
It would appear from the responses to phase-shifting light-dark cycles, considering the two-process model of sleep-wake control, that the more-directly-light-responsive core is associated better with the homeostatic aspect of sleep-wake regulation, whereas the shell is better associated with the circadian modulation of sleep wake.
Consistent with the above, obesity-resistant rats have increased levels of SPA in the setting of increased activity of orexin A. Another fundamental function of orexin is the modulation of sleep, a function underlined by the neuroanatomical connections between the endogenous clock, the suprachiasmatic nucleus, and orexin cell bodies.
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Studies suggest that melatonin might help restore the circadian modulation of REM sleep in people with REM sleep behavior disorder, and thereby normalize REM sleep.
As it is widely known that the LC neurons also play an important role in the modulation of REM sleep, therefore, we reason that the proton pump would also modulate REM sleep, but the NHE would not.
Here, the effects of mGlu7 receptor selective modulation on sleep and wake states are explored.
Separate roles for the two OXR subtypes on sleep architecture that fit well with their differential distribution have been postulated; namely, a specific role in the regulation of REM sleep for OX1R in the locus coeruleus [30] and an implication of hypothalamic OX2R in the modulation of NREM sleep [4].
Modulation of the sleep state dependent P50 midlatency auditory-evoked potential by electric stimulation of acupuncture points.
Modulation of the sleep-wake cycle with Modafinil as well as Alprazolam also had beneficial effects on cognitive function and improved apathy [17].
More suggestions(15)
modulation of sleepiness
modulation of pHi
modulation of cholesterol
modulation of sunspot
modulation of attention
modulation of apoptosis
modulation of speech
modulation of x t
modulation of brain
modulation of network
modulation of grip
modulation of pain
modulation of voice
modulation of protein
modulation of huntingtin
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