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These data point to possible strategies for tuning fibrin polymer mechanical properties through modulation of single fiber mechanics.
Several studies have shown that modulation of single miRNAs such as miR-2111,36, let-7d13 and miR-1458 inhibits or ameliorates the development of allergic airway inflammation in mice.
The Shh-VEGF-Notch-Hey2 signaling pathway controls the proliferation process, and experimental modulation of single components of this pathway alters etsrp+ cell numbers at the LPM.
In HEK293-cells we show differential modulation of single L-VDCC activity by coexpression of several human cardiac β-subunits: Unlike β1 or β3 isoforms, β2a and β2b induce a high-activity channel behavior typical of failing myocytes.
Proinflammatory cytokines have been implicated in the pathogenesis of organ dysfunction during sepsis, but the modulation of single gene products (TNFα, IL-1β, inducible nitric oxide synthase) and nonpeptide mediators (platelet-activating factor, prostaglandin or leukotriene inhibitors) has not been shown to improve mortality in sepsis and septic shock [ 41].
The modulation of single inflammatory pathways (for example, TNFα [ 5]) and generalised immune suppression with steroids [ 6, 7] has proved unsuccessful in the past, reflecting the complex pathogenesis of sepsis and leading to a reevaluation of the mechanisms that may underlie it.
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Tseng, P., Judy, J. W. & Di Carlo, D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.
The modulation of single-phase turbulence due to bubble was analysed based on the turbulence intensity, isotropy ratio (IR), length scales, specific energy dissipation rates and energy spectra.
Therefore, 2 n -WFRFT is a compatible modulation system of "single carrier," "multi-carrier," and "hybrid carrier" modulations.
Therefore, we needed to estimate the quantity and statistical significance of the signal carried by the firing rate modulation of individual neurons on single-trials.
Metabolic variants were clearly discriminated while pathways that support metabolic flexibility towards modulation of a single enzyme were elucidating.
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