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Unsurprisingly, the results highlighted modulation of signalling events associated with the inflammatory response.
As suggested for V. harvey, the modulation of signalling pathways essential to the antimicrobial immune response is an additional way to attack and escape the host response [ 103].
Modulation of signalling in the dopaminergic reward system is also suggested as an additional mechanism for the action of some appetite suppressants [ 13, 14].
Differentiation of hPSCs to cardiomyocytes can be achieved in vitro by modulation of signalling pathways that are involved in cardiac development during embryogenesis.
Modulation of signalling pathways that impact clonal conversion will improve stem cell self-renewal and engraftment, together with the long-term maintenance of the regenerated epidermis in transplanted patients.
The modulation of signalling pathways by antioxidants could thus help prevent cancer by preserving normal cell cycle regulation, inhibiting proliferation, inducing apoptosis, inhibiting tumor invasion and angiogenesis, suppressing inflammation, and stimulating detoxification enzyme activity [ 30, 82, 83].
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In addition, indirectly acting factors, such as diet and environmental factors, may contribute to the development of cancer via the modulation of signaling pathways of intestinal epithelial cells.
It is responsible for intracellular modulation of signaling pathways.
Interestingly, however, recent studies have shown that proliferation of mammalian cardiomyocytes can be re-activated by experimental modulation of signaling pathways [9].
Recently modulation of signaling cascades with other interacting proteins is acquiring more relevance, as is the case in the STAT pathway [27] and in NFAT responses [28].
The strong modulation of signaling networks in monocytes suggests that this cell subset may be involved in clinical responses to CTLA4 blockade.
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