Balanced modulation of several targets is one of the current strategies for the treatment of multi-factorial diseases.
Therefore, the mechanism of action of CBD must include the modulation of several pathways that, together, improve cellular metabolism and confer neuroprotection, which may account for rescuing the functional deficits observed in our model10.
In fact, despite having employed in such studies different proteomic strategies based on 2DE, DIGE and SILAC, the modulation of several proteins (like VIM, PKM2, THBS1) in CS-treated chondrocytes has been observed also in this study (Table 3).
The observed beneficial effects can be attributed at least in part to the direct modulation of several enzymatic activities by its polyphenolic constituents.
The control of light propagation in a Photonic Crystal (PhC) slab can occur through the modulation of several parameters [1].
After practice, response time decreased in all participants (while accuracy remained consistent), and electrophysiological measures revealed modulation of several ERP components.
Gi proteins reduce neurones excitability through the inhibition of adenylate cyclase activity and modulation of several K+ and Ca2+ channels [17].
Optimization of a secondary metabolite phenotype, such as ergosterol production, obviously depends on the modulation of several genes.
In accordance with this observation, SMILE silencing in HeLa cells correlated with the modulation of several transcripts involved in proteolysis and a decrease in proteasome activity.
In conclusion, our study revealed expression modulation of several TRIM genes by two different signaling pathways involved in triggering antiviral responses.
Immune activation after a recent exposure may be associated with activation and modulation of several immune markers and the magnitude and timing of pro- and down-regulatory cytokines may be very important for TST conversion during a natural exposure.
