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If our observations are generalizable, neuropeptide transcriptional reporters provide a way to dissect tonic modulation of secretory activity in neural networks.
It is conceivable that, for Leishmania, at least one of the advantages of the LGT mediated acquisition of META1 was additional modulation of secretory processes.
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Modulation of the secretory pathway could be related to adhesion, motility and invasion, given that all the molecular players in these processes are either soluble secreted proteins (chemokines) or membrane receptors that need to be folded, modified and delivered by the secretory pathway.
It has been reported that spermidine transporter demonstrates an important role in signal modulation of Type III secretory system [ 100].
A significant element that separates invadopodia from focal adhesions is the modulation of the cell's secretory machinery and the focal secretion of ECM-degrading matrix metalloproteases (MMPs) that ultimately allow the breach of tissue boundaries [ 43].
Their results show that 8 days of DBZ treatment elicits homogenous goblet cell conversion throughout the small intestine and colon, which is associated with a quantitative but not qualitative modulation of the genes encoding secretory mucins (i.e. MUC2 is overexpressed without ectopic expression of gastric MUC5AC and MUC6 genes).
Our data show that Lkb1 is required for the normal differentiation of secretory cell lineages within the intestine, and that Lkb1 deficiency modulates Notch signalling modulation in post-mitotic cells.
This work provides important mechanistic insights into the modulation of neuronal transport and highlights BICDR-1 as a regulatory factor that coordinates the direction of secretory cargo transport in differentiating neurons.
The function of the SCCs in the lower airway still needs to be determined, but may involve local modulation of the airway epithelium (mucociliary clearance and secretory functions; [ 60]) or induction of a local response of the innate immune system.
Expression of secretory mucin genes by human conjunctival epithelia.
Sweat gland, either of two types of secretory skin glands occurring only in mammals.
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