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Recent reports have suggested that orexins, also known as hypocretins, play an important role in the modulation of respiratory control in mammals, but there are no data available describing the role of the orexinergic system in the peripheral and central chemoreception of non-mammalian vertebrates.
Ca2+ changes within the mitochondria have important functional consequences, including the modulation of respiratory chain activity.
The rodent external lateral nucleus is involved in respiratory function and in the modulation of respiratory responses to hypoxia and hypercapnia [ 35, 36].
A potential explanation for this phenotype is that removal of BACE1 from highly metabolically active tissues such as BAT and skeletal muscle causes inefficient energy metabolism through modulation of respiratory function (uncoupling).
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These fast modulations of respiratory dynamics suggest that olfactomotor control could be similar to that of vision or audition [40].
Modulation of the respiratory rhythm is one of the most important functions of the brainstem.
The modulation of the respiratory rhythm is closely associated with the brainstem.
Because modulation of the respiratory rhythm is one of the most important functions of the brainstem, patients with DLB may exhibit dysrhythmic breathing.
This type of extrinsic gating is exemplified by the mammalian carotid chemoreflex modulation of the respiratory rhythm in which separate STP and STD chemoreflex afferent pathways are temporally gated to either the inspiratory or expiratory phase of the respiratory pattern generator (Fig. 4).
Modulation of the different respiratory pathways has mainly been reported for source organs and increasing sources (González-Meler et al., 2001; Millenaar and Lambers, 2003).
Effect of central structures as a source of respiratory modulation could not be excluded [27].
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