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A major novel finding is the modulation of proteins involved in glutamatergic signalling.
Proteomic analysis of Fe-starved tomato roots [ 16] showed a positive modulation of proteins related to metabolism of methionine (e.g. methionine synthase), a precursor of nicotianamine.
Previous studies with exponentially growing S. cerevisiae reported that metabolic reconfiguration occurred to cope with oxidative stress by inhibiting glycolysis and elevating the pentose phosphate pathway, which is anti-oxidative, via rapid modulation of proteins and gene expression [ 33].
No difference in the treatment-induced modulation of proteins involved in cell cycle progression (cyclin A, cdk2, pRB, E2F-1) apoptosisosis (bcl-2, bax) was observed in the three clones.
We detected the modulation of proteins involved in several processes, such as cartilage ECM structural organization (three proteins, including noncollagenous proteins and proteoglycans), ECM remodeling (four proteins, including proteases and their inhibitors), immune response (six proteins) and angiogenesis (two proteins).
Along with others, we have recognized vigorous modulation of proteins and gene expression early after start of conventional chemotherapy, but there is limited knowledge on signal transduction modulation in AML blasts in patients undergoing therapy.
Similar(52)
Kirchhofer, A. et al. Modulation of protein properties in living cells using nanobodies.
Mayya, V. et al. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
His research group focuses on the development of new chemical technologies for the discovery and modulation of protein-protein interactions.
Monks, C.R., Kupfer, H., Tamir, I., Barlow, A. & Kupfer, A. Selective modulation of protein kinase C-θ during T-cell activation.
Lau, K. H. A., Bang, J., Hawker, C. J., Kim, D. H. & Knoll, W. Modulation of protein-surface interactions on nanopatterned polymer films.
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