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Since SSA has been described as being involved in chemotaxis of inflammatory cells, modulation of proinflammatory cytokines and endothelial cell proliferation [24] [28], the present data support a possible role of SSA in the development of ScGVHD.
Their activities are related to the modulation of proinflammatory cytokines.
Modulation of proinflammatory cytokines by Leishmania species in vitro and in vivo is reported elsewhere [ 6].
In particular, modulation of proinflammatory cytokines, such as TNF α, is currently under investigations.
Our data demonstrated statistically significant modulation of proinflammatory and anti-inflammatory cytokine production in animals treated with IFN-β.
The modulation of proinflammatory and anti-inflammatory mediators, as previously demonstrated [ 1], may improve microcirculation, tissue perfusion and cellular oxygenation.
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It has been demonstrated that exposure of monocytes or immature dendritic cells to soluble SEMA4D/CD100, the first semaphorin characterized within the immune system, resulted in a significant down-modulation of proinflammatory cytokine production [52].
A particular advantage of gelsolin therapy over previously failed immunomodulary therapies derives from its modulation of multiple proinflammatory pathways.
This inconsistency reflects the difficulty to apprehend the beneficial and harmful effects of the modulation of both proinflammatory and anti-inflammatory processes.
This effect was independent of CD14 or LPS-binding protein (LBP) and suggests a specific and unique role for MD-2 in LPS recognition that contributes to modulation of the proinflammatory response of effector cells [ 37].
Since the general function of IL-10 is modulation and downregulation of proinflammatory responses, the protective effect of IL-10 in chicken embryos could be mediated by an immune-modulatory function which downregulates an otherwise destructive proinflammatory response, thus differing from its role in candidiasis in mice.
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