However, it can also infer condition-specific modulation of post-translational TF activity when used in conjunction with gene sets consisting of putative TF targets.
These results suggest that while feedback mechanisms between protein abundance and transcript levels exist, the majority of the effects observed here for both hfq and smpB are a result of direct modulation of post-transcriptional events.
The objective of our study was to determine, through modulation of post-stroke inflammatory response, to what extent microglial cells are involved in some specific events of neuronal plasticity, neurite outgrowth and synaptogenesis.
Metabolic modulation of post-ischemic myocardium and advanced left ventricular dysfunction is an important and emerging area of therapeutic investigation.
In addition to its crucial role in virus entry and trafficking, many viruses activate PI3K signalling for modulation of post-internalization events such as virus replication and assembly (highlighted in Diehl and Schaal, 2013).
Acute NPC delivery yields long-term neuroprotection via enhanced BBB integrity and modulation of post-ischemic immune responses, whereas post-acute NPC delivery increases post-ischemic angioneurogenesis and axonal plasticity.
In conclusion, acute NPC delivery results in sustained neuroprotection via stabilization of the BBB and modulation of post-ischemic immune responses, whereas late post-acute NPC delivery enhances post-ischemic angioneurogenesis and axonal plasticity.
That assertion is intimated in the initial portions of the paper, however the reply makes clear that the central issue is rather, why did the Multi-TI pCASL method reveal such "highly significant and robust" activation only in the dpIns after whole-brain correlation with subjective ratings of tonic "pain intensity" elicited by thermal modulation of post-capsaicin cutaneous hyperalgesia.
We find that the anti-inflammatory activity of miR-146a/b is mediated by suppression of pro-inflammatory transcription factors (i.e., NF-κB, EGR-1/3, AP-1) as well as through modulation of post-transcriptional pro-inflammatory pathways (mediated by the targeting of HuR).
Given that the mRNA transcriptome was invariant and the proposed biochemistry of skeletal muscle insulin resistance, modulation of post-translational and metabolic processes is a logical finding, while our analysis highlights muscle development, possibly regulation of muscle stem-cell status, as being of potential importance.
Attentional modulations of sensory-specific P1 and N1 components are usually interpreted as evidence for the intraperceptual sensory gating of attended locations within visual perception (Mangun, 1995), while longer-latency effects are likely to reflect attentional modulations of post-perceptual processes (Mangun and Hillyard, 1991).
