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The mechanisms proposed include metabolic changes (restricting glycolysis, increasing fatty acid oxidation, mitochondrial respiration and ATP synthesis), increased GABAergic inhibition, modulation of oxidative stress and neuroprotection [ 63].
Modulation of oxidative stress as an anticancer strategy.
Gorrini, C., Harris, I. S. & Mak, T. W. Modulation of oxidative stress as an anticancer strategy.
Natural products are suggested to provide protection against EC-induced toxicity through the modulation of oxidative stress.
Exercise can mitigate the age-related brain losses through the modulation of oxidative stress parameters, CTSB, and BDNF circulating levels, these improving neural mechanisms of redox homeostasis, and BDNF and CTSB signaling.
Modulation of oxidative stress in tumor tissues, inhibition of the formation of angiogenesis factors, and subsequent reduction in tumor vessel density and the nutrient supply to tumor cells could be important mechanisms by which fullerenol aggregates inhibit tumor growth and suppress carcinoma metastasis in vivo.
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Yu et al. examined the modulation of oxidative-stress resistance and associated regulatory mechanisms by CUR also in a C. elegans model.
The effect is not the outcome of increased tissue Fe but of NO-modulation of oxidative changes that may favour conversions of internal Fe to more readily available ferrous iron.
This effect was supported by bacteria beneficial effect on photochemical apparatus and the modulation of its oxidative stress machinery.
The current study explored whether zinc supplementation protects against diabetic nephropathy through modulation of kidney oxidative stress and stress-induced expression related to the inflammatory process in streptozotocin-induced diabetic rats.
The present study was designed to investigate whether the modulation of brain oxidative status and/or BDNF content, as assessed in adulthood, are involved with the functional neuroprotection caused by environmental enrichment in animals receiving neonatal HI.
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