It indicates that the differences in water oxidation observed by Murakami et al. [ 18] were not caused by direct modulation of water oxidation on Mn4CaO5 cluster, but rather by some indirect effect.
The mechanisms proposed include metabolic changes (restricting glycolysis, increasing fatty acid oxidation, mitochondrial respiration and ATP synthesis), increased GABAergic inhibition, modulation of oxidative stress and neuroprotection [ 63].
Guo, J. et al. Proteome-wide light/dark modulation of thiol oxidation in cyanobacteria revealed by quantitative site-specific redox proteomics.
Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.
This latter point is of particular interest as we and others have proposed a similar role for modulation of fatty acid oxidation and energy production in the establishment of persistent HCV and measles virus infection [ 2, 37].
Finally, favorable modulation of mitochondrial oxidative capacity in skeletal muscle by exercise training may reduce a block for complete oxidation of fatty acids in muscle and thereby relieve a block to effective insulin signaling.
The effect of slow ON OFF liquid flow modulation on the oxidation of aqueous solutions of ethanol using a 0.5%Pd/Al2O33 commercial egg-shell catalyst was investigated in a laboratory trickle bed reactor (TBR).
Genes affecting monocyte recruitment [e.g. CD14 receptor polymorphisms] [51], lipid transport [e.g., cholesteryl ester transport protein (CETP)] [52], lipid oxidation, and modulation of the inflammatory response to oxidized lipids may also help explain differences in susceptibility of populations to developing atherosclerosis [53].
These results are consistent with our CV experiments showing that the sequence of oxidation potential modulation for theses isomers is para (hydroquinone) > ortho (catechol) > > meta (resorcinol) as shown in Table 1.
Modulation of enzyme activity by cysteine oxidation to sulfenic acid has been reported: thiol oxidation has been shown to participate in the catalytic mechanism of peroxiredoxins (Prx) isoforms I-VI, which reduce H2O2 by forming disulphide [39], sulfenic acid (in Cys51 in mammals) [40], [41].
One implication of our results is that limiting rapid fat loss and mitochondrial beta oxidation via modulation of FLP-7 secretion may be the principal mechanism underlying the increased lifespan of AMPK overexpression43.
